AZothBio

iSTAs

iSTAs - Workflow

iSTAs - Ai Deep Learning Key Modules

DDiSTA

  • CPP Sequence &
    LNP Prediction
    AiCPP / AiLNP
    Prediction of CPP
    sequence and LNPs that can be used as a vehicle to targeted intracellular organelles with various cargos
    (in-house library)
    AiTope
    Prediction of peptide sequence that can be used as the antigen for cancer, virus therapies
    (MHC-I / MHC-II)

MoliSTA

  • Activity
    Screening
    AiCAD / AiCAD-S
    Prediction of leads’ selectivity and strength of activity on various cancer types.
    Discovery of the optimal indication including MOA
    AiKPro / AiGPro
    Prediction of on / off target activity at targeted kinase and GPCR
  • Generating
    Molecules
    AiMol-Optimization
    Analyzing physical and chemical characteristics of molecular structure using mathematical approach to rebuild structures. Prediction of bioactivity including adverse effects
    AiMol-Assembly
    Generating new molecules (Scaffold) by combining two different ones, based on molecular structure, and bioactivity data.
  • Modification
    Optimization
    AiSAR
    Analysis on 3D structure activity of leads, and prediction of adverse effect and toxicity through analyzing similarity

    ADMET prediction & optimization
    AiP450
    Lead optimization by scoring and prediction of hepatotoxicity

    Prediction of inhibition ratio on CYP450

ArchiSTA

Biochemistry database
- Digitization and curation of biochemistry research data

In house data

  • NIH
  • COSMIC
  • PubChem
  • ChEMBL
  • Drug Target

Digitization

  • small molecule small molecule
  • DNA / Protein DNA / Protein
  • Literature, etc. Literature, etc.
  • self-produced self-produced

Curation

Database for MoliSTA and DDiSTA

Database for MoliSTA and PepiSTA

MoliSTA

MoliSTA

  • Anticancer

    • Phenotype Screening
    • MOA Analysis
  • On-Off

    Target

    • On Target
    • Off Target
    • Structure Analysis
  • Optimization

    • Molecular Generating
    • MOA Analysis
  • AiCAD
  • AiCADs
  • AiKPro
  • AiGPro
  • AiP450
  • AiSAR
  • AiMol
  • CLE
  • CSE
  • SBDD
New Lead

DDiSTA

- AZothBio helps to deliver a variety of therapeutics extensively using cell penetrating peptides

AiCPP

Prediction and Generation of Cell Penetrating Peptide Sequence

AiCPP
AiCPP

AiTope 1

MHC Class I Epitope Prediction

AiTope 1

AiTope 2

MHC Class II Epitope Prediction

AiTope 2

- Prediction of the correct sequence of cell penetrating peptides and LNPs delivering to our target organelles with our in-house delivery library

Delivery Library (CPP & LNP)

  • Cargo
    Antigen
    siRNA
    Small molecule drug
    mRNA (in progress)
  • Cell
    Dendritic Cell
    (Neoantigen Presenting Cell)
    T Cell/B Cell
    Muscle/Skin Cell
  • Cellular Organelle
    ER
    Mitochondria
    (in progress)
    Nucleus
    Golgi
  • Application
    Anti-Cancer Vaccine
    Gene Therapy
    Virus Vaccine
    Immune Therapy
    Cell Therapy

Neoantigen Discovering Tool

  • Antigen Targeting
    Anti cancer-Neoantigen
    Covid-19 shared antigen
    Customized(HLA type)-Neoantigen
    Targeting disease based-Neoantigen
  • Immune System Selection
    CD8+ T Cell (MHC-1 presentation)
    CD4+ T Cell (MHC-2) (in progress)
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